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Gallic acid and omega-3 fatty acids decrease inflammatory and oxidative stress in manganese-treated rats.
Experimental Biology and Medicine ( IF 3.2 ) Pub Date : 2020-04-06 , DOI: 10.1177/1535370220917643
Solomon E Owumi 1 , Sarah O Nwozo 2 , Magdalene E Effiong 2 , Eseroghene S Najophe 2
Affiliation  

Evidence abounds—epidemiological and experimental—linking overexposure to manganese with hepatic and renal dysfunction. We investigated the beneficial effects of gallic acid or omega-3 fatty acids (ω-3-FA) on hepatorenal function in rats exposed to manganese (Mn). Rats were exposed to manganese (15 mg/kg) only or in the presence of ω-3-FA (30 mg/kg) or gallic acid (20 mg/kg) continuously for 14 days. Gallic acid or ω-3-FA co-treatment significantly (P < 0.05) suppressed manganese-mediated increases in the biomarkers of hepatorenal toxicity. Furthermore, gallic acid or ω-3-FA relieved manganese-induced oxidative stress, lipid peroxidation, and glutathione depletion.In addition to decreases in nitric oxide, interleukin-1β, tumor necrosis factor-α levels, and myeloperoxidase concentration in treated rats, biochemical data on hepatorenal protection were buttressed by our histological findings. Gallic acid or ω-3-FA ameliorated manganese-induced hepatorenal toxicity by reducing the oxidative/inflammatory stress and preserved tissue integrity in rats.

Impact statement

Humans and animals are regularly exposed to toxic chemicals with subsequent adverse effects. Manganese exposure occurs via contaminated sources; over-exposure is associated with neuronal, hepatorenal dysfunction, etc. This work advances the field of natural chemopreventive agents by reporting evidence lacking in the literature on GA and ω-3-FA obtained primarily from the diet in protecting biological beings against toxic chemicals. Individually, GA and ω-3-FA exhibit various pharmacological effects. Our findings confirm the previous reports; however, we demonstrate the additional evidence for GA and ω-3-FA in abating toxic response incumbent on oxidative damage associated with manganese exposure. These findings further underscore the relevance of GA usage in food, cosmetics–pharmaceutical industries, and ω-3-FA as a safe supplement. Dietary supplements with GA and fish oil-rich in ω-3FA may be the potential natural therapy against hepatorenal injury in individuals inadvertently or occupationally exposed to manganese, thereby, promoting human and veterinary health outcomes.



中文翻译:

没食子酸和omega-3脂肪酸可减轻锰治疗大鼠的炎症和氧化应激。

大量的证据(流行病学和实验)将过度暴露于锰与肝和肾功能不全联系在一起。我们研究了没食子酸或ω-3脂肪酸(ω-3-FA)对暴露于锰(Mn)的大鼠肝肾功能的有益作用。大鼠仅暴露于锰(15 mg / kg)或在ω-3-FA(30 mg / kg)或没食子酸(20 mg / kg)存在下连续暴露14天。没食子酸或ω-3-FA共同处理(P < 0.05)抑制了锰介导的肝肾毒性生物标志物的增加。此外,没食子酸或ω-3-FA可缓解锰引起的氧化应激,脂质过氧化和谷胱甘肽耗竭。除了降低一氧化氮,白介素-1β,肿瘤坏死因子-α水平和髓过氧化物酶浓度外,我们的组织学发现支持了有关肝肾保护的生化数据。没食子酸或ω-3-FA通过减少大鼠的氧化/炎症应激并保留了组织完整性,改善了锰诱导的肝肾毒性。

影响陈述

人和动物定期接触有毒化学物质,会产生随后的不良影响。锰暴露是通过污染源发生的。过度暴露与神经元,肝肾功能不全等有关。这项工作通过报道文献中缺乏主要从饮食中获得的GA和ω-3-FA证据来保护生物体免受有毒化学物质的侵害,从而推动了天然化学预防剂领域的发展。GA和ω-3-FA分别具有多种药理作用。我们的发现证实了以前的报告;但是,我们证明了GA和ω-3-FA在减轻与锰暴露相关的氧化损伤所引起的毒性反应方面的其他证据。这些发现进一步强调了在食品,化妆品,制药工业和ω-3-FA作为安全补充剂中使用GA的相关性。

更新日期:2020-04-20
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