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Prognostic value of non-invasive fibrosis indices post-curative resection in hepatitis-B-associated hepatocellular carcinoma patients.
Experimental Biology and Medicine ( IF 3.2 ) Pub Date : 2020-03-29 , DOI: 10.1177/1535370220914252
Ting-Ting Zhang 1 , Si-Si Ye 2 , Jun Liang 3 , Li Bai 2
Affiliation  

Non-invasive fibrosis indices, according to regular laboratory and clinical data, could be useful in assessing liver fibrosis in chronic hepatitis patients. However, the role of these biomarkers remains unclear in predicting the outcome of HBV-associated HCC in patients. This study was carried out retrospectively and included a relatively large sample size (n = 405) with a heterogeneous population of HBV infected patients and longer duration of prospective follow-up. Our study suggested that APRI and Fibro-α Scores are inversely correlated with overall survival in HBV-associated HCC patients. Meanwhile, GUCI, King Score, and APRI were highly correlated with cirrhosis status. Also, in subgroups of cirrhosis or non-cirrhosis, Fibro-α Scores could differentiate patients with good prognosis from those with poor outcome. This result would aid clinicians in acquiring preventive and therapeutic methods in patients with high risk.

中文翻译:

乙型肝炎相关肝细胞癌根治性切除术后无创纤维化指标的预后价值。

根据常规实验室和临床数据,非侵入性纤维化指数可能有助于评估慢性肝炎患者的肝纤维化。然而,这些生物标记物在预测患者HBV相关HCC结局方面的作用尚不清楚。这项研究是回顾性进行的,其中包括相对较大的样本量(n = 405),且异质性感染了HBV的患者人群和较长的随访时间。我们的研究表明,APRI和Fibro-α得分与HBV相关HCC患者的总体生存率呈负相关。同时,GUCI,King Score和APRI与肝硬化状态高度相关。同样,在肝硬化或非肝硬化的亚组中,Fibro-α评分可以将预后良好的患者与预后差的患者区分开。
更新日期:2020-04-20
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