Ovarian aging is becoming a more important issue in terms of fertility preservation and infertility treatment. Serum anti-Mullerian hormone (AMH) level and antral follicle count (AFC) are being practically used as markers of ovarian aging as well as ovarian reserve in human. However, these factors have some drawbacks in assessing ovarian aging and reserve. Therefore, the identification of ovarian expressions of BMP15, GDF9, and C-KIT according to female could be applied as a potent predictor of ovarian aging. This work provides new information on the development of diagnosis and treatment strategy of age-related fertility decline and premature ovarian insufficiency.

中文翻译：

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使用BMP15，GDF9和C-KIT的卵巢表达预测卵巢衰老。

就生育力保存和不孕症治疗而言，卵巢衰老正变得越来越重要。血清抗Mullerian激素（AMH）水平和肛门卵泡计数（AFC）实际上被用作人类卵巢衰老和卵巢储备的标志物。但是，这些因素在评估卵巢衰老和储备方面有一些缺点。因此，根据女性确定的BMP15，GDF9和C-KIT卵巢表达可作为预测卵巢衰老的有效方法。这项工作为与年龄相关的生育力下降和卵巢早衰的诊断和治疗策略的发展提供了新的信息。