Sphingosine kinases type 1 (SphK1) is a key enzyme in the phosphorylation of sphingosine to sphingosine 1‐phosphate (S1P). Different abnormalities in SphK1 functions may correspond with poor prognosis in various cancers. Additionally, upregulated SphK1/S1P could promote cancer cell proliferation, angiogenesis, mobility, invasion, and metastasis. MicroRNAs as conserved small noncoding RNAs play major roles in cancer initiation, progression, metastasis, etc. Their posttranscriptionally mechanisms could affect the development of cancer growth or tumorigenesis suppression. The growing number of studies has described that various microRNAs can be regulated by SphK1, and its expression level can also be regulated by microRNAs. In this review, the relationship of SphK1 and microRNA functions and their interaction in human malignancies have been discussed. Based on them novel treatment strategies can be introduced.

中文翻译：

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Sphk1 / S1P与microRNA在人类癌症中的关系

1型鞘氨醇激酶（SphK1）是将鞘氨醇磷酸化为1磷酸鞘氨醇（S1P）的关键酶。SphK1功能的不同异常可能与各种癌症的不良预后相对应。此外，上调的SphK1 / S1P可以促进癌细胞增殖，血管生成，迁移，侵袭和转移。MicroRNA作为保守的非编码小RNA在癌症的发生，进展，转移等方面起着重要作用。它们的转录后机制可能会影响癌症的发展或抑制肿瘤的发生。越来越多的研究表明，SphK1可以调控多种microRNA。，其表达水平也可以通过microRNA调节。在这篇综述中，已经讨论了SphK1和microRNA功能的关系及其在人类恶性肿瘤中的相互作用。基于它们，可以引入新颖的治疗策略。