What if the next generation of successful treatments was hidden in the current pharmacopoeia? Identifying new indications for existing drugs, also called the drug repurposing or drug rediscovery process, is a highly efficient and low-cost strategy. First reported almost a century ago, drug repurposing has emerged as a valuable therapeutic option for diseases that do not have specific treatments and rare diseases, in particular. This review focuses on Hutchinson-Gilford progeria syndrome (HGPS), a rare genetic disorder that induces accelerated and precocious aging, for which drug repurposing has led to the discovery of several potential treatments over the past decade.

中文翻译：

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Hutchinson-Gilford 早衰综合症：使旧药恢复活力以对抗加速衰老

如果下一代成功的治疗方法隐藏在当前的药典中怎么办？确定现有药物的新适应症，也称为药物再利用或药物再发现过程，是一种高效、低成本的策略。近一个世纪前首次报道，药物再利用已成为一种有价值的治疗选择，尤其是对于没有特定治疗方法的疾病和罕见疾病。本综述重点关注哈钦森-吉尔福德早衰综合征 (HGPS)，这是一种罕见的遗传疾病，可导致加速和早熟衰老，在过去十年中，药物再利用导致发现了几种潜在的治疗方法。