当前位置: X-MOL 学术Nat. Rev. Immunol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
COVID-19: immunopathology and its implications for therapy.
Nature Reviews Immunology ( IF 100.3 ) Pub Date : 2020-05-01 , DOI: 10.1038/s41577-020-0308-3
Xuetao Cao 1, 2
Affiliation  

Severe coronavirus disease 2019 (COVID-19) is characterized by pneumonia, lymphopenia, exhausted lymphocytes and a cytokine storm. Significant antibody production is observed; however, whether this is protective or pathogenic remains to be determined. Defining the immunopathological changes in patients with COVID-19 provides potential targets for drug discovery and is important for clinical management. In the short time since SARS-CoV2 emerged, much has been learned about the immunopathology of the infection. Here, Xuetao Cao discusses what these early insights imply for drug discovery and clinical management.

中文翻译:

COVID-19:免疫病理学及其对治疗的影响。

2019 年严重冠状病毒病 (COVID-19) 的特征是肺炎、淋巴细胞减少、淋巴细胞衰竭和细胞因子风暴。观察到显着的抗体产生;然而,这是保护性的还是致病性的仍有待确定。确定 COVID-19 患者的免疫病理学变化为药物发现提供了潜在的靶点,对临床管理很重要。自 SARS-CoV2 出现以来的短时间内,人们对感染的免疫病理学有了很多了解。在这里,曹雪涛讨论了这些早期见解对药物发现和临床管理的意义。
更新日期:2020-04-09
down
wechat
bug