BACKGROUND Data relating to the association between inflammatory bowel disease (IBD) and pregnancy outcomes are lacking in Korea. AIMS To determine the incidence rates of pregnancy outcomes in women with IBD. METHODS A nationwide population study was performed using the Korean National Health Insurance claims database. A total of 2058 women with IBD consisting of ulcerative colitis (UC, n = 1469) and Crohn's disease (CD, n = 589) were pregnant between 2007 and 2016. We compared their incidence of pregnancy outcomes with 20 580 age-matched controls without IBD. We also stratified the patients into those with quiescent to mild and moderate to severe IBD and compared the outcomes between them. RESULTS The pregnancy rate of women with IBD was lower than that of women without (25.7% vs 32.3%, P < 0.001). Caesarean section (46.5% vs 38.8%, odds ratio [OR] 1.43, 95% confidence interval [CI]: 1.17-1.75), and intrauterine growth retardation (IUGR) (3.0% vs 1.0%, OR 2.89, 95% CI: 1.59-5.26) were increased in CD patients than the controls. In regards to disease severity, there were no significant differences in pregnancy outcomes between patients with quiescent to mild IBD and the controls. However, the live birth rate of patients with moderate to severe IBD was lower than that of the controls (65.0% vs 69.9%, OR 0.79, 95%CI: 0.66-0.94). In addition, moderate to severe IBD was significantly associated with spontaneous abortion (14.9% vs 11.9%, OR 1.33, 95% CI: 1.04-1.68), caesarean section (46.4% vs 38.8%, OR 1.41, 95% CI: 1.14-1.74) and IUGR (3.4% vs 1.0%, OR 3.20, 95% CI: 1.75-5.84). CONCLUSIONS With the exception of moderate to severe disease, the incidences of adverse pregnancy outcomes in women with IBD are similar to that of the general population.

中文翻译：

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炎症性肠病妇女的妊娠结局：一项为期10年的全国性人群研究。

背景技术在韩国缺乏与炎症性肠病（IBD）和妊娠结局之间的关联有关的数据。目的确定IBD妇女妊娠结局的发生率。方法使用韩国国民健康保险理赔数据库进行了全国人口研究。在2007年至2016年之间，共有2058名患有溃疡性结肠炎（UC，n = 1469）和克罗恩氏病（CD，n = 589）的IBD妇女怀孕。我们将他们的妊娠结局发生率与20 580名年龄相匹配的对照组进行了比较IBD。我们也将患者分为静态，轻度，中度至重度IBD患者，并比较了两者之间的结局。结果患有IBD的女性的怀孕率低于没有IBD的女性（25.7％vs 32.3％，P <0.001）。剖腹产（46.5％vs 38.8％，CD患者的比值比[OR] 1.43，95％置信区间[CI]：1.17-1.75）和宫内发育迟缓（IUGR）（3.0％vs 1.0％，OR 2.89，95％CI：1.59-5.26）增加比控件。关于疾病的严重程度，静止至轻度IBD的患者与对照组之间的妊娠结局无显着差异。但是，中重度IBD患者的活产率低于对照组（65.0％vs 69.9％，或0.79，95％CI：0.66-0.94）。此外，中度至重度IBD与自然流产（14.9％vs 11.9％，或1.33，95％CI：1.04-1.68），剖宫产（46.4％vs 38.8％，或1.41，95％CI：1.14-）显着相关。 1.74）和IUGR（3.4％vs 1.0％，或3.20，95％CI：1.75-5.84）。结论除了中度至重度疾病，