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Anti-obesity effect of Melandrium firmum Rohrbach extract in 3T3-L1 cells and high-fat diet-induced obese C57BL/6N mice.
Food Science & Nutrition ( IF 3.9 ) Pub Date : 2020-04-08 , DOI: 10.1002/fsn3.1466
Hyun-Yong Kim 1 , Ju Hee Kim 2 , Guanglei Zuo 1 , Soon Sung Lim 1, 2, 3
Affiliation  

In this study, we first investigated the influence of Melandrium firmum Rohrbach (MF) on the accumulation of lipid content in 3T3‐L1 cells and in vitro results showed that MF extraction suppressed the differentiation of 3T3‐L1 pre‐adipocytes in a concentration‐dependent manner without showing cytotoxicity. Hence, we studied the effects of MF on preventing obesity in C57BL/6N mice. The results showed that MF decreased food efficiency ratio, body weight, epididymal adipose and hepatic tissue weight, hepatic lipid metabolites, and triacylglycerol and cholesterol serum levels, when compared with the high‐fat diet group. Moreover, MF significantly inhibited the expression of genes related to adipogenesis, such as PPAR‐γ, C/EBP‐α, and aP2, and those related to lipogenesis, such as SREBP‐1c, FAS, SCD‐1, and CD36 in epididymal adipose and liver tissues. These anti‐adipogenic and anti‐lipogenic effects of MF suggest that it could be used as a food including potential functional ingredient to prevent high‐fat diet‐induced obesity.

中文翻译:

刚果罗汉巴提取物对3T3-L1细胞和高脂饮食诱导的肥胖C57BL / 6N小鼠的抗肥胖作用。

在这项研究中,我们首先研究了黑麦草的影响Rohrbach(MF)对3T3-L1细胞中脂质含量的积累和体外结果显示,MF提取以浓度依赖的方式抑制3T3-L1前脂肪细胞的分化,而没有显示细胞毒性。因此,我们研究了MF对预防C57BL / 6N小鼠肥胖的作用。结果表明,与高脂饮食组相比,MF降低食物利用率,体重,附睾脂肪和肝组织重量,肝脂质代谢产物以及三酰甘油和胆固醇血清水平。此外,MF明显抑制附睾中与脂肪形成有关的基因(例如PPAR-γ,C /EBP-α和aP2)以及与脂肪形成有关的基因(例如SREBP-1c,FAS,SCD-1和CD36)的表达脂肪和肝组织。
更新日期:2020-04-08
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