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A concise total synthesis and PPAR activation activity of hericerin from Hericium erinaceum.
The Journal of Antibiotics ( IF 3.3 ) Pub Date : 2020-04-08 , DOI: 10.1038/s41429-020-0303-8
Zhongyong Zheng 1, 2 , Baosong Chen 1, 2 , Kai Wang 3 , Li Bao 1, 2 , Zhengdi Wang 4 , Liping Xie 4 , Changbin Guo 4 , Hongwei Liu 1, 2
Affiliation  

Hericerin is an isoindolinone meroterpenoid alkaloid isolated from medicinal mushroom Hericium erinaceum with some bioactivities. Herein, a concise total synthesis of hericerin was described, with four steps and 30% overall yield starting from commercially available methyl 3-hydroxy-5-methoxybenzoate and geranyl bromide. A comprehensive effect of hericerin on HepG2 cell line was observed and confirmed by transcriptomic analysis. Furthermore, hericerin was found to be a new PPARγ agonist.



中文翻译:

猴头菇中hericerin的简明总合成和PPAR活化活性。

Hericerin是从药用蘑菇猴头菇中分离出来的具有某些生物活性的异吲哚啉酮类萜金属生物碱。本文中,描述了hericerin的简明全合成,从商业上可获得的3-羟基-5-甲氧基苯甲酸甲酯和香叶基溴开始四个步骤,总收率达到30%。观察到了Hericerin对HepG2细胞系的综合作用,并通过转录组分析证实了这一作用。此外,发现hericerin是一种新的PPARγ激动剂。

更新日期:2020-04-08
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