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Water-soluble proteins as an excipient for drug administration by inhalation
Russian Chemical Bulletin ( IF 1.7 ) Pub Date : 2020-03-01 , DOI: 10.1007/s11172-020-2806-7
A. E. Boldyrev , M. A. Ziganshin , N. M. Lyadov , A. E. Klimovitskii , A. V. Gerasimov

Microspherical particles of composite drugs based on lysozyme and albumin, which can be used in inhalation administration, were prepared by spray drying. The composition of the complexes was determined using experimental and theoretical methods. The use of the protein matrix makes it possible to increase the dissolution rate of the drug in water. The obtained results can be useful for the development of new drug dosage forms with increased bioavailability.

中文翻译:

水溶性蛋白质作为吸入给药的赋形剂

采用喷雾干燥法制备了可用于吸入给药的溶菌酶和白蛋白复合药物微球颗粒。使用实验和理论方法确定复合物的组成。蛋白质基质的使用可以提高药物在水中的溶解速度。获得的结果可用于开发具有更高生物利用度的新药物剂型。
更新日期:2020-03-01
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