Bisphenol compounds (BPs), as a group of endocrine disrupted compounds, have been posing serious risk on ecological environment and human health. The sensing of BPs is quite significant, but still in challenge. Here, we report, for the first time, a metal-organic framework (MOF) directly and alone, enables the selective and sensitive detection of BPs on its unique fluorescent change. This MOF is based on Ga(III) ion, and interestingly represents specific fluorescent behavior of “turn on” and “turn off”. It exhibits not only good sensing capability with the detection limits as low as 26.36 nM (6.02 μg/L) for the typical BPs (bisphenol A), but also excellent selectivity toward the BPs on the synchronous fluorescent changes of “turn on” at 320 nm and “turn off” at 382 nm. Where, this phenomenon is caused by π-π stacking and hydrogen bonding interactions between adsorbed bisphenol molecules and the MOF host, demonstrated by molecular simulations. More importantly, the proposed sensing method based on this MOF is applicable in the detection of BPs in drinking water, showing excellent performance.

双酚化合物（BPs）作为一组内分泌干扰化合物，已经对生态环境和人类健康构成严重风险。对BP的感知非常重要，但仍面临挑战。在这里，我们首次直接和单独报告了金属有机框架（MOF），能够对其独特的荧光变化进行BP的选择性和灵敏检测。此MOF基于Ga（III）离子，有趣地表示“打开”和“关闭”的特定荧光行为。它不仅具有良好的感测能力，而且对于典型的BP（双酚A）的检出限低至26.36 nM（6.02μg/ L），而且在320的“开启”同步荧光变化下对BP具有出色的选择性。并在382 nm处“关闭”。哪里，这种现象是由π-π堆积和吸附的双酚分子与MOF主体之间的氢键相互作用引起的，这通过分子模拟得到了证明。更重要的是，基于该MOF提出的传感方法可应用于饮用水中BP的检测，具有良好的性能。