OBJECTIVE Ayahuasca is a hallucinogenic plant preparation, traditionally consumed in sacred ceremonies by indigenous North-Westerner Amazonian countries like Colombia, Peru, Brazil, and Ecuador. It is fundamental to carefully balance benefits/risks related to the ayahuasca intake, both during ceremonies and experimental settings. The aim is at evaluating and comparing the potential therapeutic benefits versus health risks related to ayahuasca intake (both acutely and chronically), focusing on its application in psychedelic psychiatry. DESIGN A comprehensive mini overview focusing on psychiatric outcomes following ayahuasca intake both in healthy volunteers and in clinical samples. RESULTS Preclinical, observational, and experimental studies in healthy volunteers as well as in clinical samples suggest that ayahuasca may be beneficial as an antidepressant, emotional regulator, anxiolytic, and antiaddictive drug, by exerting fast-acting and enduring clinical effects. Ayahuasca appears to be safe and well tolerated, nausea and emesis being the most reported and transient side effects. Some findings suggest not to use ayahuasca in bipolar or psychotic patients because of an increased risk of manic switch and/or psychotic onset. CONCLUSIONS Further research should be carried out in randomized, double-blind, placebo-controlled trials, by implementing neuroimaging studies, in order to better evaluate therapeutic potential of ayahuasca in mental disorders.

中文翻译：

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从精神病学的角度来看，阿育吠陀如何起作用？促生疗法的利弊。

目的Ayahuasca是一种致幻植物制剂，传统上是由西北土著亚马逊国家（如哥伦比亚，秘鲁，巴西和厄瓜多尔）在神圣的仪式中食用的。在仪式和实验环境中，认真平衡与to鱼摄入相关的收益/风险是至关重要的。目的是评估和比较与阿育吠陀摄入量（急性和慢性）有关的潜在治疗益处与健康风险，重点是其在迷幻精神病学中的应用。设计全面的迷你概述，重点关注健康志愿者和临床样本中摄入hua鱼后的精神病学预后。结果临床前，观察性，在健康志愿者以及临床样本中进行的实验研究表明，树花可能具有抗抑郁，情绪调节，抗焦虑和抗成瘾的作用，可发挥速效和持久的临床作用。Ayahuasca似乎是安全且耐受良好的，恶心和呕吐是最常报告和短暂的副作用。一些发现表明，由于躁狂转换和/或精神病发作的风险增加，因此在双相或精神病患者中不要使用ayahuasca。结论应通过实施神经影像学研究，在随机，双盲，安慰剂对照试验中进行进一步研究，以更好地评估阿育吠陀在精神疾病中的治疗潜力。通过发挥速效和持久的临床效果。Ayahuasca似乎是安全且耐受良好的，恶心和呕吐是最常报告和短暂的副作用。一些发现表明，由于躁狂转换和/或精神病发作的风险增加，因此在双相或精神病患者中不要使用ayahuasca。结论应通过进行神经影像学研究，在随机，双盲，安慰剂对照试验中进行进一步研究，以更好地评估阿育吠陀在精神疾病中的治疗潜力。通过发挥速效和持久的临床效果。Ayahuasca似乎是安全且耐受良好的，恶心和呕吐是最常报告和短暂的副作用。一些发现表明，由于躁狂转换和/或精神病发作的风险增加，因此在双相或精神病患者中不要使用ayahuasca。结论应通过实施神经影像学研究，在随机，双盲，安慰剂对照试验中进行进一步研究，以更好地评估阿育吠陀在精神疾病中的治疗潜力。