Exosomes, as natural occurring vesicles, play highly important roles in the behavior and fate of ischemic diseases and different tumors. Secretion, composition, and function of exosomes are remarkably influenced by hypoxia in ischemic diseases and tumor microenvironment. Exosomes secreted from hypoxic cells affect development, growth, angiogenesis, and progression in ischemic diseases and tumors through a variety of signaling pathways. In this review article, we discuss how hypoxia affects the quantity and quality of exosomes, and review the mechanisms by which hypoxic cell‐derived exosomes regulate ischemic cell behaviors in both cancerous and noncancerous cells.

中文翻译：

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缺氧如何调节缺血性疾病和癌症微环境中的外泌体？

外泌体作为天然存在的囊泡，在缺血性疾病和不同肿瘤的行为和命运中起着非常重要的作用。缺血性疾病和肿瘤微环境中的缺氧显着影响外泌体的分泌、组成和功能。缺氧细胞分泌的外泌体通过多种信号通路影响缺血性疾病和肿瘤的发育、生长、血管生成和进展。在这篇综述文章中，我们讨论了缺氧如何影响外泌体的数量和质量，并回顾了缺氧细胞衍生的外泌体在癌细胞和非癌细胞中调节缺血细胞行为的机制。