Meningiomas are among the most common primary brain tumors. There is a growing need for novel ways of differentiating between benign (World Health Organization [WHO] grade I) and atypical (WHO grade II) meningiomas as well as for novel markers of the tumor's future behavior. A difference between glucose metabolism in atypical and benign meningiomas is well known. However, a significant correlation between the systemic metabolic status of the patient and the meningioma WHO grade has not yet been established. Our aim was to compare the WHO grades of intracranial meningiomas with the patient's HbA1c levels as a more reliable marker of the chronic systemic metabolic status than the fasting blood glucose value, which is usually looked at. We retrospectively analyzed 15 patients and compared their meningioma WHO grade with their preoperative HbA1c values. Our results show that patients with benign intracranial meningiomas have significantly lower HbA1c value. Conversely, patients with atypical intracranial meningiomas have higher HbA1c values. Furthermore, we showed that the proliferation factor Ki67 was statistically strongly correlated with the HbA1c value (p < .001. These results imply a possible positive correlation between meningioma cell proliferation and the chronic systemic glycemia. Further research in this area could not only lead to better understanding of meningiomas but could have significant clinical application.

中文翻译：

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颅内脑膜瘤 WHO I 级和 II 级患者的 HbA1c：一项初步研究

脑膜瘤是最常见的原发性脑肿瘤之一。越来越需要区分良性（世界卫生组织 [WHO] I 级）和非典型（WHO II 级）脑膜瘤的新方法以及肿瘤未来行为的新标记。非典型脑膜瘤和良性脑膜瘤中葡萄糖代谢之间的差异是众所周知的。然而，尚未确定患者全身代谢状态与脑膜瘤 WHO 分级之间的显着相关性。我们的目的是将颅内脑膜瘤的 WHO 分级与患者的 HbA1c 水平进行比较，将其作为慢性全身代谢状态的更可靠标志，而不是通常观察的空腹血糖值。我们回顾性分析了 15 名患者，并将他们的脑膜瘤 WHO 分级与术前 HbA1c 值进行了比较。我们的结果表明，良性颅内脑膜瘤患者的 HbA1c 值显着降低。相反，非典型颅内脑膜瘤患者的 HbA1c 值较高。此外，我们发现增殖因子 Ki67 与 HbA1c 值在统计学上有很强的相关性（p < .001。这些结果暗示脑膜瘤细胞增殖与慢性全身血糖之间可能存在正相关。在该领域的进一步研究不仅可以导致更好地了解脑膜瘤，但可能具有重要的临床应用。非典型颅内脑膜瘤患者的 HbA1c 值较高。此外，我们发现增殖因子 Ki67 与 HbA1c 值在统计学上有很强的相关性（p < .001。这些结果暗示脑膜瘤细胞增殖与慢性全身血糖之间可能存在正相关。在该领域的进一步研究不仅可以导致更好地了解脑膜瘤，但可能具有重要的临床应用。非典型颅内脑膜瘤患者的 HbA1c 值较高。此外，我们发现增殖因子 Ki67 与 HbA1c 值在统计学上有很强的相关性（p < .001。这些结果暗示脑膜瘤细胞增殖与慢性全身血糖之间可能存在正相关。在该领域的进一步研究不仅可以导致更好地了解脑膜瘤，但可能具有重要的临床应用。