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From the beginning to the present state of molecular microbial pathogenesis—A tribute to Pascale Cossart
Molecular Microbiology ( IF 3.6 ) Pub Date : 2020-03-17 , DOI: 10.1111/mmi.14450
Werner Goebel 1
Affiliation  

The universe of Molecular Microbial Pathogenesis is filled with many female and male stars. But there are two particularly bright shining supernovae‐like stars: the late Stanley Falkow and the very lively and creative Pascale Cossart. These two outstanding luminaries, surrounded by numerous planets, do not only belong to different scientific generations but their splendor also comes from very different scientific concepts. Stanley Falkow, often referred to as the ‘Father of Molecular Microbial Pathogenesis’, made many groundbreaking contributions to this field by addressing almost all important bacterial pathogens. Pascale Cossart, who could be called in analogy the ‘Queen of Modern Molecular Microbial Pathogenesis’ by combining the Microbiology and Cell Biology, concentrates in her similarly impressive scientific work essentially on a single bacterial species which she studied and still studies in great depth: the facultative intracellular bacterial pathogen Listeria monocytogenes—and the vast majority of her most prominent publications deals with this pathogen in almost all facets. It is certainly not an exaggeration to say that she together with her co‐workers and collaborators developed this model bacterium into a paradigm among the intracellular bacterial pathogens.

中文翻译:

从一开始到现在的分子微生物发病机理研究-致敬Pascale Cossart

分子微生物发病机理的宇宙充满了许多雌雄恒星。但是,有两个特别耀眼的超新星般恒星:已故的斯坦利·福尔柯(Stanley Falkow)和非常活泼且富有创造力的帕斯卡尔·科萨特(Pascale Cossart)。这两个杰出的灯具被众多行星围绕着,它们不仅属于不同的科学世代,而且它们的辉煌也来自非常不同的科学概念。斯坦利·福尔科夫(Stanley Falkow)通常被称为“分子微生物发病机理之父”,通过解决几乎所有重要的细菌病原体,为该领域做出了许多开创性的贡献。帕斯卡尔·考萨特(Pascale Cossart),通过将微生物学和细胞生物学相结合,可以被称为“现代分子微生物发病机理之王”,单核细胞增生性李斯特菌(Listeria monocytogenes)以及她最杰出的出版物中的绝大多数都涉及这种病原体。可以肯定地说,她与她的同事和合作者一起将这种典型细菌发展成为细胞内细菌病原体的典范。
更新日期:2020-03-26
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