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Frequent recovery of influenza A but not influenza B virus RNA in aerosols in pediatric patient rooms.
Indoor Air ( IF 5.8 ) Pub Date : 2020-04-13 , DOI: 10.1111/ina.12669
Eunice Yuen Chi Shiu 1 , Wenbo Huang 2 , Dan Ye 3 , Yanmin Xie 1 , Jinhan Mo 4 , Yuguo Li 5 , Benjamin John Cowling 1 , Zifeng Yang 2 , Nancy Hiu Lan Leung 1
Affiliation  

Influenza transmission occurs through the air, but the relative importance of small droplets, or aerosols, in influenza transmission especially within healthcare facilities remains uncertain. Detections of influenza virus in aerosols in cough and exhaled breath from infected patients and from the air in outpatient or inpatient healthcare facilities have been studied, but most studies were done in adults with very few data involving children. We aimed to assess the potential of influenza transmission via aerosols in pediatric patient rooms. Two‐stage cyclone (NIOSH) air samplers were used to collect the air in 5‐bed pediatric patient rooms with patients with influenza‐like illness. Influenza A virus RNA was recovered in 15/19 (79%) air sampling occasions with ≥1 patient with laboratory‐confirmed influenza A virus infections, in all air size fractions (>4 µm, 1‐4 µm and <1 µm). Influenza B virus RNA was significantly less detected (2/10 occasions, 20%). We estimated a ventilation rate of 1.46 ACH in a similar but unoccupied 5‐bed patient room. High quantities of influenza A virus RNA detected in the air in pediatric patient rooms suggests other individuals in pediatric patient rooms including other patients, visitors, caretakers and healthcare workers could be exposed to influenza A virus in aerosols while caring for infected children.

中文翻译:

在儿科患者病房中,气溶胶中的甲型流感病毒而不是乙型流感病毒RNA经常恢复。

流感是通过空气传播的,但是小滴或气溶胶在流感传播中,尤其是在医疗机构内部的相对重要性仍然不确定。已经研究了从感染患者以及门诊或住院医疗机构的空气中检测咳嗽和呼气气溶胶中流感病毒的方法,但是大多数研究是在成年人中进行的,涉及儿童的数据很少。我们旨在评估在儿科患者病房中通过气溶胶传播流感的潜力。使用两级旋风(NIOSH)空气采样器在患有流感样疾病的5床儿科病房中收集空气。在≥1名经实验室确认的甲型流感病毒感染的患者中,有15/19(79%)的空气采样机会回收了甲型流感病毒RNA,在所有尺寸的空气中(> 4 µm,1-4 µm和<1 µm)。乙型流感病毒RNA的检出率显着降低(2/10次,20%)。我们估计在类似但无人的5张病床的患者房间中的通气率为1.46 ACH。在儿科患者病房中的空气中检测到大量的甲型流感病毒RNA,这表明在儿科患者病房中的其他个人,包括其他患者,访客,看护者和医护人员,在照顾感染儿童的过程中可能会暴露于气溶胶​​中的甲型流感病毒。
更新日期:2020-04-13
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