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The developing immune network in human prenatal skin.
Immunology ( IF 6.4 ) Pub Date : 2020-04-14 , DOI: 10.1111/imm.13192
Rachel Anne Botting 1 , Muzlifah Haniffa 1, 2, 3
Affiliation  

Establishment of a well-functioning immune network in skin is crucial for its barrier function. This begins in utero alongside the structural differentiation and maturation of skin, and continues to expand and diversify across the human lifespan. The microenvironment of the developing human skin supports immune cell differentiation and has an overall anti-inflammatory profile. Immunologically inert and skewed immune populations found in developing human skin promote wound healing, and as such may play a crucial role in the structural changes occurring during skin development.

中文翻译:

人类产前皮肤中不断发展的免疫网络。

在皮肤中建立功能良好的免疫网络对其屏障功能至关重要。这从子宫开始,伴随着皮肤的结构分化和成熟,并在整个人类寿命中不断扩大和多样化。发育中的人类皮肤的微环境支持免疫细胞分化,并具有总体抗炎特性。在人类皮肤发育中发现的免疫学惰性和偏斜的免疫种群促进伤口愈合,因此可能在皮肤发育过程中发生的结构变化中起关键作用。
更新日期:2020-04-14
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