Both CD8⁺ T cells and NK cells contribute to the immune response against the protozoan Leishmania parasite. Both are able to generate IFN‐γ and both display cytotoxic features. These features may enable them to not only contribute to parasite clearance but also to cause immune‐mediated pathology. This pathology is evident, for example, in the Leismania‐induced skin lesions found in patients with cutaneous leismaniasis (CL). Here we highlight new data demonstrating that CD8⁺ T cells and NK cells in CL display a highly cytotoxic senescent phenotype, and that the senescent T cells play a major role in mediating skin pathology. This is the first demonstration that senescent CD8 T cells contribute to immunopathology in vivo.

中文翻译：

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危险老化；皮肤利什曼病中衰老CD8 T细胞的归巢。

CD8 ⁺ T细胞和NK细胞都有助于抵抗原生动物利什曼原虫的免疫反应。两者都能够产生IFN-γ，并且都具有细胞毒性特征。这些功能可能使它们不仅有助于清除寄生虫，而且还可以引起免疫介导的病理。这种病理学很明显，例如，在由Leismania引起的皮肤Leismaniasis（CL）患者中发现的皮肤病变中。在这里，我们重点介绍了新数据，这些数据表明CL中的CD8 ⁺ T细胞和NK细胞表现出高度的细胞毒性衰老表型，并且衰老T细胞在介导皮肤病理学中起主要作用。这是衰老的CD8 T细胞在体内有助于免疫病理学的第一个证明。