Insula shows abnormal task-evoked and resting-state activity in first-episode drug-naïve generalized anxiety disorder.,Depression and Anxiety

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Insula shows abnormal task-evoked and resting-state activity in first-episode drug-naïve generalized anxiety disorder.
Depression and Anxiety ( IF 7.4 ) Pub Date : 2020-03-20 , DOI: 10.1002/da.23009
Huiru Cui ₁ , Bin Zhang _{2,

3} , Wei Li ₁ , Hui Li ₁ , Jiaoyan Pang ₁ , Qiang Hu ₁ , Lanlan Zhang ₄ , Yingying Tang ₁ , Zhi Yang ₁ , Jijun Wang _{1,

5,

6,

7} , Chunbo Li _{1,

5,

6,

7} , Georg Northoff _{8,

9,

10}

Affiliation

Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China.
Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, China.
Suzhou Guangji Hospital, Suzhou, China.
CAS Center for Excellence in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of Science, Shanghai, China.
Brain Science and Technology Research Center, Shanghai Jiao Tong University, Shanghai, China.
Institute of Psychology and Behavioral Science, Shanghai Jiao Tong University, Shanghai, China.
Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, Canada.
Centre for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou, China.
Mental Health Center, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Interoception is associated with neural activity in the insula of healthy humans. On the basis of the somatic symptoms in generalized anxiety disorder (GAD), especially abnormal heartbeat perception, we hypothesized that abnormal activity in the insula was associated with interoceptive awareness in patients with GAD.

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