Decades of breakthroughs resulting from cross feeding of microbiological research and technological innovation have promoted Listeria monocytogenes to the rank of model microorganism to study host–pathogen interactions. The extraordinary capacity of this bacterium to interfere with a vast array of host cellular processes uncovered new concepts in microbiology, cell biology and infection biology. Here, we review technological advances that revealed how bacteria and host interact in space and time at the molecular, cellular, tissue and whole body scales, ultimately revolutionising our understanding of Listeria pathogenesis. With the current bloom of multidisciplinary integrative approaches, Listeria entered a new microbiology era.

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通过技术进步的棱镜，进行了三十年的李斯特菌学研究。

交叉研究微生物学研究和技术创新带来的数十年突破已将单核细胞增生性李斯特菌提升到用于研究宿主与病原体相互作用的模型微生物。这种细菌具有极大的能力来干扰大量宿主细胞过程，从而在微生物学，细胞生物学和感染生物学中发现了新的概念。在这里，我们回顾了技术进步，揭示了细菌和宿主如何在分子，细胞，组织和全身范围内按时空相互作用，最终彻底改变了我们对李斯特菌发病机理的认识。随着当前多学科整合方法的兴起，李斯特菌进入了新的微生物学时代。