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When bacteria meet mitochondria: The strange case of the tick symbiont Midichloria mitochondrii†.
Cellular Microbiology ( IF 3.4 ) Pub Date : 2020-03-17 , DOI: 10.1111/cmi.13189
Fabrizia Stavru 1, 2 , Jan Riemer 3 , Aaron Jex 4, 5, 6 , Davide Sassera 7
Affiliation  

Mitochondria are key eukaryotic organelles that perform several essential functions. Not surprisingly, many intracellular bacteria directly or indirectly target mitochondria, interfering with innate immunity, energy production or apoptosis, to make the host cell a more hospitable niche for bacterial replication. The alphaproteobacterium Midichloria mitochondrii has taken mitochondrial targeting to another level by physically colonising mitochondria, as shown by transmission electron micrographs of bacteria residing in the mitochondrial intermembrane space. This unique localization provokes a number of questions around the mechanisms allowing, and reasons driving intramitochondrial tropism. We suggest possible scenarios that could lead to this peculiar localization and hypothesize potential costs and benefits of mitochondrial colonisation for the bacterium and its host.

中文翻译:

当细菌遇到线粒体时:壁虱共生体Midichloria线粒体†的奇怪情况。

线粒体是关键的真核细胞器,具有多种基本功能。毫不奇怪,许多细胞内细菌直接或间接靶向线粒体,干扰先天免疫​​,能量产生或细胞凋亡,使宿主细胞成为细菌复制的更友好的环境。该α-变形菌Midichloria mitochondrii线粒体膜间空间中细菌的透射电子显微照片显示,它通过物理定居线粒体使线粒体靶向达到了另一个水平。这种独特的定位引发了围绕线粒体内趋向性的机制及其原因的许多问题。我们建议可能的情况,可能导致这种特殊的定位,并假设线粒体定殖对该细菌及其宿主的潜在成本和收益。
更新日期:2020-03-26
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