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Ferroptosis: Final destination for cancer?
Cell Proliferation ( IF 8.5 ) Pub Date : 2020-03-01 , DOI: 10.1111/cpr.12761
Zeng Ye 1, 2, 3, 4 , Wensheng Liu 1, 2, 3, 4 , Qifeng Zhuo 1, 2, 3, 4 , Qiangsheng Hu 1, 2, 3, 4 , Mengqi Liu 1, 2, 3, 4 , Qiqing Sun 1, 2, 3, 4 , Zheng Zhang 1, 2, 3, 4 , Guixiong Fan 1, 2, 3, 4 , Wenyan Xu 1, 2, 3, 4 , Shunrong Ji 1, 2, 3, 4 , Xianjun Yu 1, 2, 3, 4 , Yi Qin 1, 2, 3, 4 , Xiaowu Xu 1, 2, 3, 4
Affiliation  

Ferroptosis is a recently defined, non‐apoptotic, regulated cell death (RCD) process that comprises abnormal metabolism of cellular lipid oxides catalysed by iron ions or iron‐containing enzymes. In this process, a variety of inducers destroy the cell redox balance and produce a large number of lipid peroxidation products, eventually triggering cell death. However, in terms of morphology, biochemistry and genetics, ferroptosis is quite different from apoptosis, necrosis, autophagy‐dependent cell death and other RCD processes. A growing number of studies suggest that the relationship between ferroptosis and cancer is extremely complicated and that ferroptosis promises to be a novel approach for the cancer treatment. This article primarily focuses on the mechanism of ferroptosis and discusses the potential application of ferroptosis in cancer therapy.

中文翻译:

铁死亡:癌症的最终目的地?

铁死亡是最近定义的一种非凋亡调节细胞死亡 (RCD) 过程,包括由铁离子或含铁酶催化的细胞脂质氧化物的异常代谢。在此过程中,多种诱导剂破坏细胞氧化还原平衡,产生大量脂质过氧化产物,最终引发细胞死亡。然而,在形态学、生物化学和遗传学方面,铁死亡与细胞凋亡、坏死、自噬依赖性细胞死亡和其他 RCD 过程有很大不同。越来越多的研究表明,铁死亡与癌症之间的关系极其复杂,铁死亡有望成为一种新的癌症治疗方法。
更新日期:2020-03-01
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