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Resveratrol protects the integrity of alveolar epithelial barrier via SIRT1/PTEN/p‐Akt pathway in methamphetamine‐induced chronic lung injury
Cell Proliferation ( IF 8.5 ) Pub Date : 2020-03-01 , DOI: 10.1111/cpr.12773
Xin Wang 1 , Ming Liu 2 , Mei‐Jia Zhu 1 , Lin Shi 1 , Lian Liu 1 , Yuan‐Ling Zhao 1 , Lin Cheng 1 , Ying‐Jian Gu 1 , Ming‐Yuan Zhou 1 , Lei Chen 1 , Ashok Kumar 3 , Yun Wang 1
Affiliation  

SIRT1 is an antioxidative factor, but its mechanism in methamphetamine (MA)‐induced lung injury remains unclear. The purpose of this study is to determine whether MA can disrupt the integrity of alveolar epithelial barrier, whether SIRT1 is involved in MA‐induced chronic lung injury and whether Resveratrol (Res) can protect the integrity of alveolar epithelial cells by regulating ROS to activate SIRT1/PTEN/p‐Akt pathway.

中文翻译:

白藜芦醇在甲基苯丙胺诱导的慢性肺损伤中通过 SIRT1/PTEN/p-Akt 通路保护肺泡上皮屏障的完整性

SIRT1 是一种抗氧化因子,但其在甲基苯丙胺 (MA) 诱导的肺损伤中的机制尚不清楚。本研究的目的是确定MA是否可以破坏肺泡上皮屏障的完整性,SIRT1是否参与MA诱导的慢性肺损伤以及白藜芦醇(Res)是否可以通过调节ROS激活SIRT1来保护肺泡上皮细胞的完整性/PTEN/p-Akt 通路。
更新日期:2020-03-01
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