SPAG5‐AS1 inhibited autophagy and aggravated apoptosis of podocytes via SPAG5/AKT/mTOR pathway,Cell Proliferation

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SPAG5‐AS1 inhibited autophagy and aggravated apoptosis of podocytes via SPAG5/AKT/mTOR pathway
Cell Proliferation ( IF 8.5 ) Pub Date : 2020-01-19 , DOI: 10.1111/cpr.12738
Jun Xu ₁ , Yujie Deng ₂ , Yi Wang ₃ , Xiaofang Sun ₂ , Shuqin Chen ₄ , Guoxiang Fu ₁

Affiliation

Podocyte injury is a prediction marker of diabetic nephropathy (DN), and AKT/mTOR pathway–mediated inhibition of autophagy is widely reported to contribute to podocyte damage. Recent study stated that sperm‐associated antigen 5 (SPAG5) activated AKT/mTOR signalling in bladder urothelial carcinoma, indicating SPAG5 might regulate autophagy and play a role in podocyte damage.

中文翻译：

SPAG5-AS1通过SPAG5/AKT/mTOR通路抑制足细胞自噬和加重凋亡

足细胞损伤是糖尿病肾病 (DN) 的预测标志物，广泛报道 AKT/mTOR 通路介导的自噬抑制会导致足细胞损伤。最近的研究表明，精子相关抗原 5 (SPAG5) 激活膀胱尿路上皮癌中的 AKT/mTOR 信号，表明 SPAG5 可能调节自噬并在足细胞损伤中发挥作用。

更新日期：2020-01-19

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