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A novel method to improve the osteogenesis capacity of hUCMSCs with dual‐directional pre‐induction under screened co‐culture conditions
Cell Proliferation ( IF 8.5 ) Pub Date : 2019-12-09 , DOI: 10.1111/cpr.12740
Qiong Rong 1, 2 , Shuyi Li 3 , Yang Zhou 1 , Yuanming Geng 4 , Shangbin Liu 1 , Wanqiu Wu 1 , Tim Forouzanfar 3 , Gang Wu 5 , Zhiyong Zhang 6 , Miao Zhou 1
Affiliation  

Mesenchymal stem cells (MSCs) based therapy for bone regeneration has been regarded as a promising method in the clinic. However, hBMSCs with invasive harvesting process and undesirable proliferation rate hinder the extensive usage. HUCMSCs of easier access and excellent performances provide an alternative for the fabrication of tissue‐engineered bone construct. Evidence suggested the osteogenesis ability of hUCMSCs was weaker than that of hBMSCs. To address this issue, a co‐culture strategy of osteogenically and angiogenically induced hUCMSCs has been proposed since thorough vascularization facilitates the blood‐borne nutrition and oxygen to transport in the scaffold, synergistically expediting the process of ossification.

中文翻译:

一种在筛选共培养条件下通过双向预诱导提高 hUCMSCs 成骨能力的新方法

基于间充质干细胞 (MSCs) 的骨再生疗法被认为是临床上一种很有前途的方法。然而,具有侵入性采集过程和不良增殖率的 hBMSCs 阻碍了其广泛使用。HUCMSCs 更容易获得和优异的性能为组织工程骨结构的制造提供了一种替代方案。有证据表明,hUCMSCs 的成骨能力弱于 hBMSCs。为了解决这个问题,已经提出了成骨和血管生成诱导的 hUCMSCs 的共培养策略,因为彻底的血管化促进了血源性营养和氧气在支架中的运输,协同加速了骨化过程。
更新日期:2019-12-09
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