The transformation of cytotrophoblasts into mesenchymal‐like extravillous trophoblasts is necessary for successful embryo implantation, and the inadequate transformation may cause abortion. Epiregulin, which is a new growth factor, plays important roles in the reproductive processes. The glycosylation of many proteins in reproduction processes is critical. Protein O‐fucosyltransferase 1 (poFUT1) is the key enzyme for the biosynthesis of O‐fucosylation on the specific glycoproteins. Urokinase‐type plasminogen activator (uPA) contains O‐fucosylated domain on Thr18. However, the functions of epiregulin and poFUT1 in the trophoblast epithelial–mesenchymal transition (EMT) process, the regulatory mechanism of epiregulin on poFUT1 and the resulting O‐fucosylated uPA remain unclear.

中文翻译：

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上皮调节蛋白通过 poFUT1 促进滋养层上皮间充质转化和 uPA 上 poFUT1 的 O-岩藻糖基化

细胞滋养细胞转化为间充质样绒毛外滋养细胞是胚胎成功植入所必需的，转化不充分可能导致流产。上皮调节蛋白是一种新的生长因子，在生殖过程中起着重要作用。许多蛋白质在繁殖过程中的糖基化是至关重要的。蛋白质 O-岩藻糖基转移酶 1 (poFUT1) 是特定糖蛋白上 O-岩藻糖基化生物合成的关键酶。尿激酶型纤溶酶原激活剂 (uPA) 在 Thr18 上含有 O-岩藻糖基化结构域。然而，上皮调节蛋白和 poFUT1 在滋养层上皮间质转化 (EMT) 过程中的功能、上皮调节蛋白对 poFUT1 的调节机制以及由此产生的 O-岩藻糖基化 uPA 仍不清楚。