Fluid in interstitial spaces accounts for ~20% of an adult body weight and flows diffusively for a short range. Does it circulate around the body like vascular circulations? This bold conjecture has been debated for decades. As a conventional physiological concept, interstitial space is a micron‐sized space between cells and vasculature. Fluid in interstitial spaces is thought to be entrapped within interstitial matrix. However, our serial data have further defined a second space in interstitium that is a nanosized interfacial transport zone on a solid surface. Within this fine space, fluid along a solid fibre can be transported under a driving power and identically, interstitial fluid transport can be visualized by tracking the oriented fibres. Since 2006, our data from volunteers and cadavers have revealed a long‐distance extravascular pathway for interstitial fluid flow, comprising at least four types of anatomic distributions. The framework of each extravascular pathway contains the longitudinally assembled and oriented fibres, working as a fibrorail for fluid flow. Interestingly, our data showed that the movement of fluid in a fibrous pathway is in response to a dynamic driving source and named as dynamotaxis. By analysis of previous studies and our experimental results, a hypothesis of interstitial fluid circulatory system is proposed.

中文翻译：

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流体在整个身体的纤维结缔组织网络中的主动界面动态传输

间隙空间中的流体约占成人体重的 20%，并在短距离内扩散流动。它是否像血管循环一样在身体周围循环？这个大胆的猜想已经争论了几十年。作为传统的生理学概念，间质空间是细胞和脉管系统之间的微米级空间。间隙空间中的流体被认为被截留在间隙基质中。然而，我们的系列数据进一步定义了间隙中的第二个空间，即固体表面上的纳米级界面传输区。在这个精细空间内，流体可以在驱动力下沿着固体纤维传输，同样，通过跟踪定向纤维可以可视化间隙流体传输。自 2006 年以来，我们来自志愿者和尸体的数据揭示了间质液流动的长距离血管外通路，包括至少四种类型的解剖分布。每个血管外通路的框架包含纵向组装和定向的纤维，作为流体流动的纤维轨道。有趣的是，我们的数据显示，流体在纤维通路中的运动是对动态驱动源的响应，称为动力性。通过对前人研究和实验结果的分析，提出了间质液循环系统假说。我们的数据表明，流体在纤维通路中的运动是对动态驱动源的响应，称为动力性。通过对前人研究和实验结果的分析，提出了间质液循环系统假说。我们的数据显示，流体在纤维通路中的运动是对动态驱动源的响应，称为动力性。通过对前人研究和实验结果的分析，提出了间质液循环系统假说。