Centrosomes nucleate and organise the microtubule cytoskeleton in animal cells. These membraneless organelles are key structures for tissue organisation, polarity and growth. Centrosome dysfunction, defined as deviation in centrosome numbers and/or structural integrity, has major impact on brain size and functionality, as compared with other tissues of the organism. In this review, we discuss the contribution of centrosomes to brain growth during development. We discuss in particular the impact of centrosome dysfunction in Drosophila and mammalian neural stem cell division and fitness, which ultimately underlie brain growth defects.

中文翻译：

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中心体：对大脑发育的好与坏

中心体在动物细胞中成核并组织微管细胞骨架。这些无膜细胞器是组织组织、极性和生长的关键结构。中心体功能障碍，定义为中心体数量和/或结构完整性的偏差，与生物体的其他组织相比，对大脑的大小和功能有重大影响。在这篇综述中，我们讨论了中心体在发育过程中对大脑生长的贡献。我们特别讨论了中心体功能障碍对果蝇和哺乳动物神经干细胞分裂和健康的影响，这最终是大脑发育缺陷的基础。