Kinetics of anti‐solvent crystallization of HNIW polymorphs were studied using in situ Raman spectroscopy and focused beam reflectance measurement (FBRM). Crystal polymorphs and supersaturation were monitored in situ by Raman spectroscopy. Crystal counts and crystal size were monitored by FBRM during anti‐solvent crystallization. The addition rate of the anti‐solvent affected the polymorph transformation, the first polymorph of the crystals, and supersaturation. At a wide range of addition rate, the unstable form, β‐form, was detected and then transformed to the stable form, ϵ‐form. By controlling the concentration and rate of addition, the stable form, ϵ‐form was only nucleated and grown without transformation. This process depended on the supersaturation and affected polymorphic transformation, concentration, nucleation rate, and growth rate, which were simultaneously monitored by Raman spectroscopy and FBRM.

中文翻译：

---

原位拉曼光谱和FBRM法研究β型和ϵ型HNIW的结晶速率

使用原位拉曼光谱和聚焦光束反射率测量（FBRM）研究了HNIW多晶型物的反溶剂结晶动力学。通过拉曼光谱法原位监测晶体多晶型物和过饱和度。在反溶剂结晶过程中，通过FBRM监控晶体数和晶体尺寸。抗溶剂的添加速率影响多晶型物的转化，晶体的第一个多晶型物和过饱和度。在很宽的添加率范围内，先检测到不稳定形式β-形式，然后转化为稳定形式β-形式。通过控制浓度和添加速率，稳定形式，β-形式仅被成核并生长而没有转化。这个过程取决于过饱和和受影响的多晶型转变，浓度，成核速率和生长速率，