Ranelate ions, employed in the past as strontium salt for the treatment of osteoporosis, exhibit a rather interesting chemistry associated with a central thiophene ring encompassing two carboxylic groups, a cyanonitrile substituent, and a nitrile diacetate group. In spite of their unfavorable reduction potentials, around 1.26 V, they react very rapidly with HAuCl₄ at room temperature, leading to decarboxylation at the C5 position in order to generate gold nanoparticles strongly stabilized by Au–C bonds. The reactions were elucidated by electrospray ionization mass spectrometry, ligand exchange kinetics, and by means of the surface‐enhanced Raman scattering effect. The gold nanoparticles were further characterized based on transmission electron microscopy and CytoViva hyperspectral microscopy.

中文翻译：

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碳键雷奈酸盐-金纳米颗粒的室温合成和拉曼光谱证据

过去用作锶盐用于治疗骨质疏松症的雷奈酸盐离子表现出与中央噻吩环有关的相当有趣的化学反应，该噻吩环包含两个羧基，一个氰腈取代基和一个二乙酸腈基。尽管它们的还原电位不利，约为1.26 V，但它们在室温下会与HAuCl ₄迅速反应，导致C5位置发生脱羧，从而生成通过Au-C键稳定的金纳米颗粒。通过电喷雾电离质谱，配体交换动力学以及表面增强拉曼散射效应阐明了反应。基于透射电子显微镜和CytoViva高光谱显微镜进一步表征了金纳米颗粒。