In this work, the cinnamaldehyde (CA) loaded nanoparticles were synthesized by directly cross‐linking chitosan hydrochloride (CSH) and sulfobutyl ether‐β‐cyclodextrin (SBE‐β‐CD). The CA/SBE‐β‐CD inclusion complex was firstly prepared, and its highest encapsulation efficiency (EE) was 86.34%. Field Emission Scanning Electron Microscope results indicated that the inclusion complex showed massive aggregates with a coarse and fluffy texture and irregular surface. Then, the inclusion complex interacted with CSH to form nanoparticles. The EE of CA in nanoparticles was improved. Atomic force microscopy showed the nanoparticles had regular and spherical morphology. Fourier transform infrared spectroscopy analysis demonstrated that CA was mainly encapsulated in the inner place of CSH/SBE‐β‐CD nanoparticles (CSNs). The enhanced thermal stability of the nanoparticles was found in differential scanning calorimeter. X‐ray diffraction implied that CA‐CSNs existed in the amorphous state. CA‐CSNs had excellent slow release property. Further, the bacteriostatic effect of CA‐CSNs was much better than that of CA and CSNs. All the results indicated that CSNs can be used as a promising carrier to encapsulate CA.

中文翻译：

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壳聚糖盐酸盐/磺基丁基醚-β-环糊精纳米粒用于肉桂醛包埋的开发及理化特性。

在这项工作中，通过直接交联壳聚糖盐酸盐（CSH）和磺丁基醚-β-环糊精（SBE-β-CD）合成了肉桂醛（CA）负载的纳米颗粒。首次制备了CA /SBE-β-CD包合物，其最高包封率（EE）为86.34％。场发射扫描电子显微镜结果表明，夹杂物呈团块状，质地粗糙蓬松，表面不规则。然后，包合物与CSH相互作用形成纳米颗粒。纳米粒中CA的EE得到改善。原子力显微镜显示纳米颗粒具有规则和球形形态。傅里叶变换红外光谱分析表明，CA主要包裹在CSH /SBE-β-CD纳米颗粒（CSN）的内部。在差示扫描量热仪中发现纳米颗粒的增强的热稳定性。X射线衍射暗示CA-CSN以非晶态存在。CA‐CSN具有出色的缓释性能。此外，CA-CSN的抑菌效果要比CA和CSN的抑菌效果好得多。所有结果表明，CSN可以用作封装CA的有希望的载体。