Conductometric and cloud point (CP) measurement studies have been performed to investigate the interaction of tetradecyltrimethylammonium bromide (TTAB) and Triton® X‐100 (TX‐100) with ciprofloxacin hydrochloride (CFH) in different solvents over the temperature range of 295.15–315.15 K. CFH is used for the treatment of various bacterial infections. The observed critical micelle concentration (CMC) values of TTAB were found to be reduced in the presence of electrolytes (Na₂SO₄/Na₃PO₄), and this reduction proceeds with the elevation of salt concentration. The order of the CMC of TTAB follows the trend:  >  >. The observed CMC values of TTAB were found to increase with increasing temperature and decrease with increasing concentration of CFH in aqueous medium. The values of Gibbs free energy of micellization () for the TTAB/TTAB + CFH mixture were found to be negative, implying spontaneous micellization. The estimated CP of TX‐100 decreases with increasing concentration of TX‐100 in aqueous medium. The CP values first decrease with increasing concentration of CFH and then increase at higher concentration of CFH almost in all cases investigated. The values of free energy of clouding were found to be positive in all cases studied implying that phase separation of TX‐100 was nonspontaneous. The other thermodynamic parameters associated with the micellization of TTAB and the phase separation of TX‐100 were estimated and explained.

中文翻译：

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不同添加剂对喹诺酮类抗生素与表面活性剂相互作用的影响：电导率和浊点测量研究

在295.15–315.15的温度范围内，进行了电导和浊点（CP）测量研究，以研究十四烷基三甲基溴化铵（TTAB）和Triton®X-100（TX-100）与盐酸环丙沙​​星（CFH）的相互作用。 K. CFH用于治疗各种细菌感染。发现在电解质（Na ₂ SO ₄ / Na ₃ PO ₄）存在下，观察到的TTAB的临界胶束浓度（CMC）值降低，并且该降低随着盐浓度的升高而进行。TTAB的CMC的顺序如下趋势： >  >。发现TTAB的CMC值随温度升高而增加，而随着CFH在水性介质中的浓度增加而降低。发现TTAB / TTAB + CFH混合物的胶束化的吉布斯自由能（）的值为负，这意味着自发胶束化。TX-100的估计CP随着水性介质中TX-100浓度的增加而降低。几乎在所有研究的情况下，CP值都随着CFH浓度的增加而先降低，然后在CFH浓度较高时增加。在所有研究的案例中，发现浑浊的自由能值为正，这表明TX-100的相分离是非自发的。估算并解释了与TTAB胶束化和TX-100相分离有关的其他热力学参数。