ABSTRACT Bromodomain AAA+ ATPases (ATPases associated with diverse cellular activities) are emerging as oncogenic proteins and compelling targets for anticancer therapies. However, structural and biochemical insight into these machines is missing. A recent study by Cho et al. reports the first cryo-EM structure of a bromodomain AAA+ ATPase and provides first insights into the functions of this putative histone chaperone.

中文翻译：

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Bromodomain AAA+ ATPases 成型

摘要溴结构域 AAA+ ATP 酶（与多种细胞活动相关的 ATP 酶）正在成为致癌蛋白和抗癌治疗的重要靶点。然而，缺乏对这些机器的结构和生化洞察力。Cho 等人最近的一项研究。报告了溴结构域 AAA+ ATPase 的第一个冷冻电镜结构，并提供了对该假定组蛋白伴侣功能的初步见解。