ABSTRACT

Reactive molecules derived from molecular oxygen and free radicals are commonly known as Reactive Oxygen Species (ROS). These molecules produce oxidative stress in cells leading to many pathological problems like diabetes, cancer, inflammation, neurodegenerative disorders, and aging. Antioxidants can remove free radicals from the human body. Therefore, it is of remarkable interest to increase the bioavailability of antioxidant drugs by increasing transdermal delivery. Nonionic surfactant vesicles or niosomes are drug carriers used to improve the dermal/transdermal bioavailability of drug supplied to the skin. The present work investigates the efficiency of ex-vivo transdermal delivery of the antioxidant plant extract A. squamosa encapsulated into niosomes using 60 exponentially decaying electroporative pulses of field strength 100 V cm⁻¹ and maximum pulse duration 4 ms. Transdermal delivery was enhanced by applying electroporative pulses with the niosomes entrapping A. Squamosa. The suggested method would help in purifying the body from harmful impurities and oxidants by topical drug enhancers that can be applied directly onto the skin.

摘要

来自分子氧和自由基的反应性分子通常称为反应性氧种（ROS）。这些分子在细胞中产生氧化应激，导致许多病理问题，例如糖尿病，癌症，炎症，神经退行性疾病和衰老。抗氧化剂可以从人体中清除自由基。因此，通过增加透皮递送来增加抗氧化剂药物的生物利用度是令人关注的。非离子表面活性剂囊泡或脂质体是用于改善提供给皮肤的药物的皮肤/透皮生物利用度的药物载体。目前的工作调查抗氧化剂植物提取物鳞球菌离体透皮递送的效率。使用60个场强100 V cm ^-1的指数衰减电穿孔脉冲和最大脉冲持续时间4 ms将其包封入脂质体。透皮传递通过施加电穿孔脉冲和包裹拟南芥的脂质体来增强。建议的方法将通过可直接应用于皮肤的局部药物增强剂帮助净化人体中的有害杂质和氧化剂。