ABSTRACT

The emerging threat of multi-drug resistance (MDR) in a wide range of diseases is a major public health problem, which prolongs treatment, imposes disabilities and reduces the expected life span. MDR is common in urinary tract infections (UTI). Due to recent dramatic change in antimicrobial activity spectrum, we evaluated the current spectrum of antimicrobials activity in UTIs. We observed 33% infection rate in cultures and positive cultures were followed by the Kirby–Bauer technique for sensitivity testing. We evaluated that females are 3.71 folds more infected than males. We observed Escherichia coli (E. coli) as the most frequent and Pseudomonas aeruginosa (P. aeruginosa) as the least (9.1%). Further, we noted that E. coli infection in males is 4.75 times of males. Moreover, Klebsiella pneumoniae (K. pneumoniae) and E. coli are 2.33 and 7.67 times more prevalent than P. aeruginosa respectively. Our sensitivity results indicate that E. coli and K. pneumoniae are resistant to the most tested antimicrobials. However, P. aeruginosa is susceptible to only few of the tested drugs which include Amikacin, Piperacillin+Tazobactam (in combination), and Ceftriaxone. We conclude, due to MDR strains we need to imitate the current strategies and propose neoadjuvant and other therapies like applied in cancer.

摘要

在多种疾病中出现的多药耐药性（MDR）威胁是一个主要的公共卫生问题，它延长了治疗时间，增加了残疾并缩短了预期寿命。MDR在尿路感染（UTI）中很常见。由于最近抗菌活性谱发生了巨大变化，我们评估了UTI中当前抗菌谱。我们观察到培养物中的感染率为33％，阳性培养后采用Kirby-Bauer技术进行敏感性测试。我们评估了女性感染率是男性的3.71倍。我们观察到大肠杆菌（E. coli）最常见，铜绿假单胞菌（P. aeruginosa）最少（9.1％）。此外，我们注意到男性的大肠杆菌感染率是男性的4.75倍。此外，肺炎克雷伯氏菌（肺炎克雷伯菌）和大肠杆菌（E.coli）是2.33和7.67倍以上普遍铜绿假单胞菌分别。我们的敏感性结果表明，大肠杆菌和肺炎克雷伯氏菌对测试最多的抗菌素具有抗性。然而，铜绿假单胞菌仅对包括阿米卡星，哌拉西林+他唑巴坦（联合使用）和头孢曲松的几种受试药物敏感。我们得出结论，由于MDR毒株，我们需要模仿目前的策略，并提出新辅助疗法和其他类似癌症的疗法。