ABSTRACT An efficient synthesis of highly substituted thiophenes was developed by means of sulfonylketenimines in a multi-step reaction including heterocumulene system containing sulfur and nitro-alkanes with acidic α-hydrogen. The speed and ease of conducting this four-component reaction under mild conditions and using available materials makes it an ideal method to synthesize high purity substituted thiophenes with sulfonamide moiety. All structures synthesized are confirmed by the instrumental analysis (EI-MS, IR and 1H /13C-NMR). GRAPHICAL ABSTRACT

中文翻译：

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磺酰基乙烯酮亚胺化学领域中多取代噻吩的合成

摘要 利用磺酰基烯酮亚胺在多步反应中开发了高取代噻吩的有效合成，包括含硫和硝基烷烃和酸性 α-氢的杂枯烯系统。在温和条件下并使用可用材料进行这种四组分反应的速度和简便性使其成为合成具有磺酰胺部分的高纯度取代噻吩的理想方法。合成的所有结构均通过仪器分析（EI-MS、IR 和 1H/13C-NMR）确认。图形概要