Abstract In this study, octadecyl amine modified graphene oxide nanoparticles were used as a potential nucleating agent in the foaming process of the polymer, to increase its functions, especially for tissue engineering purposes. It has been established that the nucleation in the polymer depends on four factors of the nanoparticle weight percentage, foaming temperature, saturation pressure and the foaming time; however, it was found that the most important and effective variables are the nanoparticle weight percentage and then the foaming temperature followed by foaming time. Polymer foams have particularly good dimensional stability, and a proper change in the process variables can control the internal structure of the foam. In this study, adding 8% of modified graphene oxide as the nucleating agent, reduced the average diameter of polyethersulfone foam cells from 4.6 to 2.7 μm, or an increase of 40 °C in foaming temperature, increased the average diameter of the cells from 2.7 to 4.3 µm. Also, the toxicity tests and biocompatibility studies showed that the porous substance made by this method is nontoxic and can be used as a scaffold in the living bodies.

中文翻译：

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使用超临界二氧化碳从改性聚醚砜/氧化石墨烯合成纳米复合泡沫的形态特性和生物相容性研究

摘要 在这项研究中，十八胺改性的氧化石墨烯纳米粒子被用作聚合物发泡过程中潜在的成核剂，以增加其功能，特别是用于组织工程目的。已经确定聚合物中的成核取决于纳米颗粒的重量百分比、发泡温度、饱和压力和发泡时间四个因素；然而，发现最重要和最有效的变量是纳米颗粒重量百分比，然后是发泡温度，然后是发泡时间。聚合物泡沫具有特别好的尺寸稳定性，适当改变工艺变量可以控制泡沫的内部结构。本研究中加入8%的改性氧化石墨烯作为成核剂，将聚醚砜泡沫泡孔的平均直径从 4.6 μm 降低到 2.7 μm，或将发泡温度提高 40 °C，泡孔的平均直径从 2.7 μm 增加到 4.3 μm。此外，毒性试验和生物相容性研究表明，该方法制备的多孔物质无毒，可用作生物体内的支架。