ABSTRACT L-glutamate, the major neurotransmitter in humans, becomes excitotoxic when present outside of protein in excess of what the healthy human was designed to accommodate; amounts readily available to consumers who ingest multiple free-glutamate-containing ingredients during a day. Studies have demonstrated that excitotoxins ingested by a mother will pass to the fetus across the placenta and pass to the newborn through mothers’ milk. The purpose of this paper is to raise awareness of the relevance of glutamate from food additives such as MSG to human brain damage, and its possible contributions to glutamate toxicity in neurodegenerative diseases, stroke, autism, schizophrenia, depression, obsessive-compulsive disorder, epilepsy, seizures, addiction, attention-deficit/hyperactivity disorder, autism, headaches, asthma, diabetes, muscle pain, atrial fibrillation, ischemia, and trauma.

中文翻译：

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谷氨酸的剂量依赖性毒性：综述

摘要 L-谷氨酸是人类的主要神经递质，当存在于蛋白质之外超过健康人设计适应的范围时，就会产生兴奋性毒性；一天摄入多种含游离谷氨酸成分的消费者可以轻松获得数量。研究表明，母亲摄入的兴奋性毒素会通过胎盘传递给胎儿，并通过母乳传递给新生儿。本文的目的是提高人们对味精等食品添加剂中的谷氨酸盐与人类脑损伤的相关性的认识，及其对神经退行性疾病、中风、自闭症、精神分裂症、抑郁症、强迫症、癫痫症中谷氨酸盐毒性的可能贡献，癫痫发作，成瘾，注意力缺陷/多动障碍，自闭症，头痛，哮喘，糖尿病，肌肉疼痛，