Abstract A new method for the preparation of sulfonamides from sodium sulfinates and amines is developed. A stoichiometric amount of m-chloroperbenzoic acid as oxidant and a catalytic amount of 1-iodopropane provides the corresponding sulfonamides in good yields under mild reaction conditions. In this protocol, 1-iodopropane is first oxidized by m-chloroperbenzoic acid into the corresponding hypervalent iodine intermediate iodosylpropane, which is highly unstable and decomposes at once to form hypoiodous acid. Then, the following reaction of the generated active hypoiodous acid with sodium sulfinates and amines results in the corresponding sulfonamides. Graphical Abstract

中文翻译：

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烷基碘通过高价碘中间体促进磺胺类药物的合成

摘要 开发了一种以亚磺酸钠和胺为原料制备磺胺类药物的新方法。化学计算量的间氯过苯甲酸作为氧化剂和催化量的 1-碘丙烷在温和的反应条件下以良好的产率提供相应的磺酰胺。在该协议中，1-碘丙烷首先被间氯过苯甲酸氧化成相应的高价碘中间体碘基丙烷，该中间体极不稳定，会立即分解形成次碘酸。然后，生成的活性次碘酸与亚磺酸钠和胺的以下反应产生相应的磺胺。图形概要