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Association between platelet count and osteoarthritis in women older than 50 years.
Therapeutic Advances in Musculoskeletal Disease ( IF 4.2 ) Pub Date : 2020-04-01 , DOI: 10.1177/1759720x20912861
Yu-Jin Kwon 1 , Il-Hyun Koh 2 , Kwangho Chung 2 , Yong-Jae Lee 3 , Hyoung-Sik Kim 4
Affiliation  

Background Osteoarthritis (OA) is a multifactorial disease involving inflammatory processes. Platelets play important roles in both hemostasis and the inflammatory response; however, the relationship between platelet count and OA is unclear. Our aim was to evaluate the association between platelet count and knee and hip OA in Korean women. Methods In this cross-sectional designed study, we included a total of 6011 women aged ⩾50 years from the 2010-2013 Korea National Health and Nutrition Examination Survey. Knee and hip OA were defined as Kellgren-Lawrence grade ⩾2 and presence of knee or hip pain, respectively. Platelet counts were divided into quartiles as follows: Q1, 150-212 (103/µl); Q2, 213-246 (103/µl); Q3, 247-283 (103/µl); and Q4, 284-450 (103/µl). Multiple logistic-regression analysis was conducted to calculate odds ratios and 95% confidence intervals. Receiver operating characteristic analysis was performed to determine the optimal platelet count cut-off with which to discriminate participants with knee and/hip OA versus those without OA. Results Of the 6011 participants, 1141 (18.1%) had knee or hip OA. The mean age of participants without OA was 60.6 years, and that of participants with OA was 68.0 years. Compared with the lowest quartile, odds ratios (95% confidence intervals) for OA were 1.08 (0.84-1.39) for Q2, 0.94 (0.73-1.23) for Q3, and 1.35 (1.08-1.69) for Q4 after adjusting for confounders. The prevalence of OA was significantly higher with platelet counts ⩾288 × 103/µl, compared with platelet counts <288 × 103/µl. Conclusion High platelet counts within the normal range are significantly associated with knee and hip OA.

中文翻译:

50 岁以上女性血小板计数与骨关节炎之间的关联。

背景骨关节炎(OA)是一种涉及炎症过程的多因素疾病。血小板在止血和炎症反应中都发挥着重要作用;然而,血小板计数与 OA 之间的关系尚不清楚。我们的目的是评估韩国女性血小板计数与膝关节和髋关节 OA 之间的关系。方法 在这项横断面设计研究中,我们纳入了来自 2010-2013 年韩国国家健康和营养调查问卷的 6011 名年龄≥50 岁的女性。膝关节和髋关节 OA 分别定义为 Kellgren-Lawrence 等级 2 和存在膝关节或髋关节疼痛。血小板计数分为四分位数如下:Q1,150-212 (103/µl);Q2, 213-246 (103/µl); Q3, 247-283 (103/µl); 和 Q4, 284-450 (103/µl)。进行多重逻辑回归分析以计算优势比和 95% 置信区间。进行接受者操作特征分析以确定最佳血小板计数截止值,用于区分患有膝关节和/髋关节 OA 的参与者与没有 OA 的参与者。结果 在 6011 名参与者中,1141 名 (18.1%) 患有膝关节或髋关节 OA。非 OA 参与者的平均年龄为 60.6 岁,而 OA 参与者的平均年龄为 68.0 岁。与最低四分位数相比,在调整混杂因素后,OA 的优势比(95% 置信区间)在 Q2 为 1.08 (0.84-1.39),Q3 为 0.94 (0.73-1.23),Q4 为 1.35 (1.08-1.69)。与血小板计数 <288 × 103/µl 相比,OA 的患病率显着高于血小板计数 288 × 103/µl。
更新日期:2020-04-21
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