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Understanding the genetic basis of congenital insensitivity to pain.
British Medical Bulletin ( IF 6.7 ) Pub Date : 2020-03-27 , DOI: 10.1093/bmb/ldaa003
Ichrak Drissi 1 , William Aidan Woods 2 , Christopher Geoffrey Woods 1
Affiliation  

Congenital insensitivity to pain (CIP) is caused by extremely rare Mendelian genetic disorders. CIP individuals demonstrate the unexpectedly severe consequences of painlessness. Although only a small number of causative conditions and genes are known, most have led to profound insights into human nociception. CIP gene discovery is catalyzing the manufacture of completely new classes of analgesics, and these are needed as alternatives to synthetic highly potent opioids.

中文翻译:

了解先天性疼痛敏感性的遗传基础。

先天性对疼痛的不敏感性(CIP)是由极为罕见的孟德尔遗传疾病引起的。CIP个人表现出无痛的出乎意料的严重后果。尽管只知道少数致病条件和基因,但大多数导致对人类伤害感受的深刻见解。CIP基因的发现正在催化新型镇痛药的生产,需要这些作为合成高效阿片类药物的替代品。
更新日期:2020-03-27
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