OBJECTIVE This study aims to evaluate the correlation between viral clearance and blood biochemical index of 94 discharged patients with COVID-19 infection in Shenzhen Third People's Hospital, enrolled from Jan 5 to Feb 13, 2020. METHODS The clinical and laboratory findings were extracted from the electronic medical records of the patients. The data were analysed and reviewed by a trained team of physicians. Information on clinical signs and symptoms, medical treatment, virus clearance, and laboratory parameters including interleukin 6 (IL-6) and C-reactive protein were collected. RESULTS COVID-19 mRNA clearance ratio was identified significantly correlated with the decline of serum creatine kinase (CK) and lactate dehydrogenase (LDH) levels. Furthermore, COVID-19 mRNA clearance time was positively correlated with the length of hospital stay in patients treated with either IFN-α + lopinavir/ritonavir or IFN-α + lopinavir/ritonavir + ribavirin. CONCLUSIONS Therapeutic regimens of IFN-α + lopinavir/ritonavir and IFN-α + lopinavir/ritonavir + ribavirin might be beneficial for treatment of COVID-19. Serum LDH or CK decline may predict a favorable response to treatment of COVID-19 infection.

中文翻译：

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94名感染COVID-19的出院患者的病毒清除率与生化结果之间的相关性。

目的本研究旨在评估2020年1月5日至2月13日在深圳市第三人民医院接受治疗的94例出院的COVID-19感染患者的病毒清除率与血液生化指标之间的相关性。方法患者的电子病历。训练有素的医师团队对​​数据进行了分析和审查。收集有关临床体征和症状，药物治疗，病毒清除率以及实验室参数（包括白介素6（IL-6）和C反应蛋白）的信息。结果确定COVID-19 mRNA清除率与血清肌酸激酶（CK）和乳酸脱氢酶（LDH）水平的下降显着相关。此外，接受IFN-α+洛匹那韦/利托那韦或IFN-α+洛匹那韦/利托那韦+利巴韦林治疗的患者中，COVID-19 mRNA清除时间与住院时间呈正相关。结论IFN-α+洛匹那韦/利托那韦和IFN-α+洛匹那韦/利托那韦+利巴韦林的治疗方案可能对COVID-19的治疗有益。血清LDH或CK下降可能预示着对COVID-19感染的治疗有良好的反应。