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Glycitin Suppresses Cartilage Destruction of Osteoarthritis in Mice.
Inflammation ( IF 5.1 ) Pub Date : 2020-03-28 , DOI: 10.1007/s10753-020-01210-3
Wenhan Wang 1, 2 , Ruitong Yang 1, 2 , Minfa Zhang 3 , Jiayi Li 2 , Jiangfan Peng 2 , Mingyang Xu 2 , Yunpeng Zhao 1 , Hao Li 1 , Xin Pan 1
Affiliation  

Abstract

Osteoarthritis (OA), a chronic joint disease, is characterized by cartilage surface erosion, subchondral bone rebuilding, and formation of osteophytes. To date, the nosogenesis and underlying mechanisms of OA have not yet been elucidated. However, it is widely accepted that TNF-α is a crucial cytokine in the development of OA. Glycitin, a natural isoflavone extracted from legumes, affects physiological reactions and pathological responses. Recently, the anti-inflammatory effect of glycitin has been reported. However, the function of glycitin in cartilage degeneration in OA remains to be investigated. In the current study, primary murine chondrocytes were isolated and stimulated by TNF-α to evaluate the anti-inflammatory effects and protective function of glycitin in chondrocytes. In vivo, the ACLT mouse model, a frequently-used OA model, was used to further examine the therapeutic role of glycitin in cartilage degeneration and inflammation in OA. Consequently, glycitin functions were examined both in vivo and in vitro. Moreover, the underlying mechanism of action of glycitin was investigated and was found to involve the NF-κB signaling pathway. Collectively, this study suggests that glycitin can be potentially used for the treatment of joint degenerative diseases, including OA.



中文翻译:

Glycitin 抑制小鼠骨关节炎的软骨破坏。

摘要

骨关节炎(OA)是一种慢性关节疾病,以软骨表面侵蚀、软骨下骨重建和骨赘形成为特征。迄今为止,OA 的发病机制和潜在机制尚未阐明。然而,人们普遍认为 TNF-α 是 OA 发展中的关键细胞因子。Glycitin 是一种从豆类中提取的天然异黄酮,影响生理反应和病理反应。最近,已经报道了大豆黄素的抗炎作用。然而,大豆黄素在 OA 软骨退变中的作用仍有待研究。在目前的研究中,分离并用 TNF-α 刺激原代小鼠软骨细胞,以评估大豆黄素在软骨细胞中的抗炎作用和保护功能。体内, ACLT 小鼠模型, 一种常用的 OA 模型, 用于进一步检查大豆黄素在 OA 软骨退行性变和炎症中的治疗作用。因此,在体内体外检测了大豆黄素功能。此外,研究了大豆黄素的潜在作用机制,发现其涉及 NF-κB 信号通路。总的来说,这项研究表明大豆黄素可以潜在地用于治疗关节退行性疾病,包括 OA。

更新日期:2020-03-30
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