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Novel therapeutic approaches of tissue engineering in male infertility
Cell and Tissue Research ( IF 3.6 ) Pub Date : 2020-02-11 , DOI: 10.1007/s00441-020-03178-w
Elham Ghanbari , Mozafar Khazaei , Maryam Ghahremani-nasab , Amir Mehdizadeh , Mehdi Yousefi

Male reproductive organ plays an important role in sperm production, maintenance and entry to the female reproductive tract, as well as generation and secretion of male sex hormones responsible for the health of male reproductive system. The purpose of this paper is to discuss the experimental and clinical evidence on the utilization of tissue engineering techniques in treating male infertility. Tissue engineering (TE) and regenerative medicine have developed new approaches to treat patients with reproductive disorders such as iatrogenic injuries, congenital abnormalities, and trauma. In some cases, including congenital defects and undescended testis or hypogonadism, the sperm samples are not retrieved. This makes TE a possible future strategy for restoration of male fertility. Here, we have summarized the recent advances in experimental and clinical application of cell-, tissue-, and organ-based regenerative medicine in male reproductive disorders.

中文翻译:

组织工程治疗男性不育的新方法

男性生殖器官在精子的产生、维持和进入女性生殖道,以及负责男性生殖系统健康的男性性激素的产生和分泌中起着重要作用。本文的目的是讨论利用组织工程技术治疗男性不育的实验和临床证据。组织工程 (TE) 和再生医学已经开发出新方法来治疗患有生殖障碍的患者,例如医源性损伤、先天性异常和外伤。在某些情况下,包括先天性缺陷和未降睾丸或性腺机能减退,精子样本不会被提取。这使得 TE 成为恢复男性生育能力的未来策略。这里,
更新日期:2020-02-11
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