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Increased Risk of Hip Fracture in Patients with Lymphoma, a Swedish Population Study of 37,236 Lymphoma Patients.
Calcified Tissue International ( IF 4.2 ) Pub Date : 2020-03-13 , DOI: 10.1007/s00223-020-00674-7
Peter Johansson 1 , Hallgerdur Lind Kristjansdottir 1 , Helena Johansson 2, 3 , Ana Jakir 1 , Dan Mellström 4, 5 , Catharina Lewerin 1
Affiliation  

Increased bone loss has been noted in lymphoma patients; however, the incidence of hip fracture is not known. The aim of our study was to explore the risk for hip fracture in patients with lymphoma compared with the entire Swedish population. The risk of hip fracture was determined in a retrospective population cohort study of adult Swedish lymphoma patients (n = 37,236), diagnosed 1995-2015 and compared with the entire Swedish population during the same period. The incidence of hip fracture in lymphoma patients was higher in women than in men, increased by age, and decreased by calendar year as also demonstrated in the total population. 2.2% of the men and 4.7% of women with lymphoma sustained a hip fracture. For the total group of females, the hazard ratio (HR) was 1.19 (95% CI 1.11-1.28) and for men, the hazard ratio was 1.06 (95% CI 0.97-1.17) compared with the Swedish population. The HR for hip fracture (2016) was 2.80 (95% CI 1.20-6.53), 2.04 (95% CI 1.30-3.20), 1.56 (95% CI 1.21-2.01), 1.08 (95% CI 0.89-1.30), and 1.07 (95% CI 0.92-1.25) in females aged 40, 50, 60, 70, and 80 years, respectively. Corresponding figures for men were not significant in 2016. Unmarried men with lymphoma had a two times higher risk for hip fracture (HR 2.02 95% CI 1.63-2.50) compared with married men. Patients with lymphoma had an increased risk of hip fracture, especially younger women and unmarried men. The incidence of hip fracture is decreased by calendar year in the lymphoma patients and the entire Swedish population.

中文翻译:

瑞典一项针对37,236名淋巴瘤患者的人群研究显示,淋巴瘤患者的髋部骨折风险增加。

淋巴瘤患者的骨质流失增加。然而,髋部骨折的发生率尚不清楚。我们研究的目的是探讨与整个瑞典人群相比,淋巴瘤患者发生髋部骨折的风险。在一项回顾性人群队列研究中确定了髋部骨折的风险,该研究对瑞典成年淋巴瘤患者(n = 37,236)进行了诊断,诊断为1995-2015年,并与同期的整个瑞典人群进行了比较。在淋巴瘤患者中,髋部骨折的发生率在女性中比男性高,随着年龄的增长而增加,并且在日历年中也有所减少,这在总人群中也得到了证实。患有淋巴瘤的男性中有2.2%,女性中有4.7%患有髋部骨折。对于全部女性,危险比(HR)为1.19(95%CI 1.11-1.28),而对于男性,危险比为1.06(95%CI 0.97-1)。17)与瑞典人口相比。髋部骨折(2016)的HR为2.80(95%CI 1.20-6.53),2.04(95%CI 1.30-3.20),1.56(95%CI 1.21-2.01),1.08(95%CI 0.89-1.30)和40岁,50岁,60岁,70岁和80岁的女性分别为1.07(95%CI 0.92-1.25)。2016年男性的相关数据并不重要。未婚男性淋巴瘤患者发生髋部骨折的风险是已婚男性的两倍(HR 2.02 95%CI 1.63-2.50)。淋巴瘤患者发生髋部骨折的风险增加,尤其是年轻女性和未婚男性。历年,在淋巴瘤患者和整个瑞典人群中,髋部骨折的发生率降低。40岁,50岁,60岁,70岁和80岁的女性分别为07(95%CI 0.92-1.25)。2016年男性的相关数据并不重要。未婚男性淋巴瘤患者的髋部骨折风险是已婚男性的两倍(HR 2.02 95%CI 1.63-2.50)。淋巴瘤患者发生髋部骨折的风险增加,尤其是年轻女性和未婚男性。历年,在淋巴瘤患者和整个瑞典人群中,髋部骨折的发生率降低。40岁,50岁,60岁,70岁和80岁的女性分别为07(95%CI 0.92-1.25)。2016年男性的相关数据并不重要。未婚男性淋巴瘤患者发生髋部骨折的风险是已婚男性的两倍(HR 2.02 95%CI 1.63-2.50)。淋巴瘤患者发生髋部骨折的风险增加,尤其是年轻女性和未婚男性。历年,在淋巴瘤患者和整个瑞典人群中,髋部骨折的发生率降低。尤其是年轻女性和未婚男性。历年,在淋巴瘤患者和整个瑞典人群中,髋部骨折的发生率降低。尤其是年轻女性和未婚男性。历年,在淋巴瘤患者和整个瑞典人群中,髋部骨折的发生率降低。
更新日期:2020-03-13
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