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A Study on the Biocompatibility of MgO Coating Prepared by Anodic Oxidation Method on Magnesium Metal
Journal of Bionic Engineering ( IF 4 ) Pub Date : 2020-01-17 , DOI: 10.1007/s42235-020-0006-7 Yangmei Chen , Xugang Lu , Fenghua Zhao , Yi Hu , Shibing Xiong , Yuqiang Guo , Ping Huang , Bangcheng Yang
Journal of Bionic Engineering ( IF 4 ) Pub Date : 2020-01-17 , DOI: 10.1007/s42235-020-0006-7 Yangmei Chen , Xugang Lu , Fenghua Zhao , Yi Hu , Shibing Xiong , Yuqiang Guo , Ping Huang , Bangcheng Yang
Magnesium (Mg), is widely used for the bone repair in oral and orthopedic application due to excellent bioactivity, degradation and biocompatibility. However, the range of application is greatly limited because of the rapid degradation of Mg metal in the body. Surface modification is an effective method to enhance the corrosion resistance and reduce the degradation rate of Mg metal. In the present study, pure Mg metal (P-Mg) was subjected to alkali-heat treatment (AT-Mg) or anodic oxidation-heat treatment (AO-HT-Mg). Both AT-Mg and AO-HT-Mg had a layer of MgO on their surfaces after treatment. Then the effects of MgO coating on corrosion resistance, bioactivity, Mesenchymal Stem Cells’ (MSCs) proliferation, adhesion and osteogenic differentiation, and the bone repair capability of Mg metal were investigated. We found both AT-Mg and AO-HT-Mg had stronger corrosion resistance than P-Mg. MSCs on both AT-Mg and AO-HT-Mg had higher expression of proteins and genes of ALP, OCN, Col-I and Runx2 than those on P-Mg. They also showed better bone repair property than P-Mg in vivo. In general, MgO layer formed by anodic oxidation-heat treatment had better resistance and biocompatibility than that produced by alkali-heat treatment. This study indicated the MgO coating not only improved the corrosion resistance of Mg metal, but also promoted the osteogenic differentiation of MSCs and bone regeneration.
中文翻译:
镁金属阳极氧化法制备MgO涂层的生物相容性研究
镁(Mg)由于具有出色的生物活性,降解性和生物相容性而被广泛用于口腔和整形外科应用中的骨修复。然而,由于镁金属在体内的快速降解,其应用范围受到极大限制。表面改性是提高耐蚀性和降低镁金属降解率的有效方法。在本研究中,对纯Mg金属(P-Mg)进行碱热处理(AT-Mg)或阳极氧化热处理(AO-HT-Mg)。处理后,AT-Mg和AO-HT-Mg的表面都有一层MgO。然后研究了MgO涂层对Mg金属的耐腐蚀性,生物活性,间充质干细胞(MSCs)增殖,粘附和成骨分化以及骨修复能力的影响。我们发现AT-Mg和AO-HT-Mg都比P-Mg具有更强的耐腐蚀性。在AT-Mg和AO-HT-Mg上的MSC均比在P-Mg上的ALP,OCN,Col-1和Runx2的蛋白质和基因表达更高。他们还显示出比P-Mg更好的骨骼修复特性。通常,通过阳极氧化热处理形成的MgO层具有比通过碱热处理产生的MgO层更好的电阻和生物相容性。这项研究表明,MgO涂层不仅提高了Mg金属的耐腐蚀性,而且还促进了MSC的成骨分化和骨骼再生。通过阳极氧化热处理形成的MgO层比通过碱热处理产生的MgO层具有更好的电阻和生物相容性。这项研究表明,MgO涂层不仅提高了Mg金属的耐腐蚀性,而且还促进了MSC的成骨分化和骨骼再生。通过阳极氧化热处理形成的MgO层比通过碱热处理产生的MgO层具有更好的电阻和生物相容性。这项研究表明,MgO涂层不仅提高了Mg金属的耐腐蚀性,而且还促进了MSC的成骨分化和骨骼再生。
更新日期:2020-01-17
中文翻译:
镁金属阳极氧化法制备MgO涂层的生物相容性研究
镁(Mg)由于具有出色的生物活性,降解性和生物相容性而被广泛用于口腔和整形外科应用中的骨修复。然而,由于镁金属在体内的快速降解,其应用范围受到极大限制。表面改性是提高耐蚀性和降低镁金属降解率的有效方法。在本研究中,对纯Mg金属(P-Mg)进行碱热处理(AT-Mg)或阳极氧化热处理(AO-HT-Mg)。处理后,AT-Mg和AO-HT-Mg的表面都有一层MgO。然后研究了MgO涂层对Mg金属的耐腐蚀性,生物活性,间充质干细胞(MSCs)增殖,粘附和成骨分化以及骨修复能力的影响。我们发现AT-Mg和AO-HT-Mg都比P-Mg具有更强的耐腐蚀性。在AT-Mg和AO-HT-Mg上的MSC均比在P-Mg上的ALP,OCN,Col-1和Runx2的蛋白质和基因表达更高。他们还显示出比P-Mg更好的骨骼修复特性。通常,通过阳极氧化热处理形成的MgO层具有比通过碱热处理产生的MgO层更好的电阻和生物相容性。这项研究表明,MgO涂层不仅提高了Mg金属的耐腐蚀性,而且还促进了MSC的成骨分化和骨骼再生。通过阳极氧化热处理形成的MgO层比通过碱热处理产生的MgO层具有更好的电阻和生物相容性。这项研究表明,MgO涂层不仅提高了Mg金属的耐腐蚀性,而且还促进了MSC的成骨分化和骨骼再生。通过阳极氧化热处理形成的MgO层比通过碱热处理产生的MgO层具有更好的电阻和生物相容性。这项研究表明,MgO涂层不仅提高了Mg金属的耐腐蚀性,而且还促进了MSC的成骨分化和骨骼再生。