Elongation factor P (EF-P) is a translation protein factor that plays an important role in specialized translation of consecutive proline amino acid motifs. EF-P is an essential protein for cell fitness in native environmental conditions. It regulates synthesis of proteins involved in bacterial motility, environmental adaptation and bacterial virulence, thus making EF-P a potential drug target. In the present study, we determined the solution and crystal structure of EF-P from the pathogenic bacteria Staphylococcus aureus at 1.48 Å resolution. The structure can serve as a platform for structure-based drug design of novel antibiotics to combat the growing antibiotic resistance of S. aureus.

中文翻译：

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核磁共振和晶体结构研究金黄色葡萄球菌的延伸因子P。

延伸因子P（EF-P）是一种翻译蛋白因子，在连续脯氨酸氨基酸基序的专门翻译中起重要作用。EF-P是天然环境条件下细胞适应性所必需的蛋白质。它调节涉及细菌运动性，环境适应性和细菌毒性的蛋白质的合成，因此使EF-P成为潜在的药物靶标。在本研究中，我们以1.48Å的分辨率确定了来自病原细菌金黄色葡萄球菌的EF-P的溶液和晶体结构。该结构可以用作新型抗生素基于结构的药物设计的平台，以对抗金黄色葡萄球菌不断增长的抗生素耐药性。