Purpose

A prospective study was conducted to evaluate signal changes in the dentate nucleus, globus pallidus, pons, and thalamus (normalized to the deep cerebellum white matter) in T1-weighted magnetic resonance (MR) images after serial injections of gadobutrol in patients with thalassemia without neurological lesions.

Methods

In this study three groups were scanned at both 1.5 T and 3 T: 15 thalassemia patients transfused and chelated with ≥4 gadobutrol administrations at a high dose (0.2 mmol/kg per scan) for late gadolinium enhancement (LGE) cardiovascular MR, 8 thalassemia patients and 13 healthy subjects who had never received gadolinium-based contrast agents (GBCA).

Results

Signal intensity (SI) ratios at 1.5 T in all regions were comparable among the three groups and were not correlated with the number of gadobutrol administrations.

In healthy subjects SI ratios were significantly different among the 4 regions, being higher in the pallidus.

The SI ratios at 1.5 T were significantly higher and not correlated with SI ratios at 3 T or with iron overload in the same regions assessed by the T2* technique.

Conclusion

This article describes the lack of increased SI in T1-weighted MR images after repeated administration of gadobutrol for cardiovascular MR studies in a high-risk population (high dose per scan, iron overload that can facilitate the transmetalation of gadolinium) scanned at 3 T and 1.5 T.

中文翻译：

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多次给予高剂量钆布醇进行心脏磁共振后，高危患者脑中不存在 T1 高信号

目的

进行了一项前瞻性研究，以评估连续注射钆布醇的地中海贫血患者在 T1 加权磁共振 (MR) 图像中齿状核、苍白球、脑桥和丘脑（标准化为小脑深部白质）的信号变化。神经病变。

方法

在这项研究中，对三组进行了 1.5 T 和 3 T 扫描：15 名地中海贫血患者输注和螯合≥4 次高剂量钆布醇给药（每次扫描 0.2 mmol/kg）用于晚期钆增强 (LGE) 心血管 MR，8 名地中海贫血患者患者和 13 名从未接受过钆造影剂 (GBCA) 的健康受试者。

结果

所有区域在 1.5 T 时的信号强度 (SI) 比在三组之间具有可比性，并且与钆布醇给药次数无关。

在健康受试者中，4 个区域的 SI 比率显着不同，苍白区更高。

1.5 T 时的 SI 比率显着更高，并且与 3 T 时的 SI 比率或与 T2* 技术评估的相同区域中的铁过载无关。

结论

本文描述了在 3 T 和1.5吨。