Abstract

Wound dressing materials which are capable of meeting the demands of accelerating wound closure and promoting wound healing process have being highly desired. Electrospun nanofibrous materials show great application potentials for wound healing owing to relatively large surface area, better mimicry of native extracellular matrix, adjustable waterproofness and breathability, and programmable drug delivery process. In this review article, we begin with a discussion of wound healing process and current commercial wound dressing materials. Then, we emphasize on electrospun nanofibrous materials for wound dressing, covering the efforts for controlling fiber alignment and morphology, constructing 3D scaffolds, developing waterproof-breathable membrane, governing drug delivery performance, and regulating stem cell behavior. Finally, we finish with challenges and future prospects of electrospun nanofibrous materials for wound dressings.

Graphic Abstract

中文翻译：

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用于伤口愈合的电纺纳米纤维材料

摘要

迫切需要能够满足加速伤口闭合和促进伤口愈合过程的伤口敷料材料。电纺纳米纤维材料由于具有相对较大的表面积，更好地模仿天然细胞外基质，可调节的防水性和透气性以及可编程的药物输送过程，因此在伤口愈合方面显示出巨大的应用潜力。在这篇评论文章中，我们首先讨论伤口愈合过程和当前的商业伤口敷料。然后，我们重点介绍用于伤口敷料的电纺纳米纤维材料，涉及控制纤维排列和形态，构建3D支架，开发防水透气膜，控制药物输送性能以及调节干细胞行为的工作。最后，

图形摘要