Abstract

A series of new 1,2,3-triazole derivatives were designed and synthesised through Cu(I) catalysed 1,3-dipolar cycloaddition of alkynes and organic azides namely click reaction, under both conventional and microwave irradiation methods. Higher yields were achieved in lesser time under microwave irradiation method by using CuI as the catalyst. Herein, the two triazole moieties are linked through the O-alkoxy oxime linkage. All the synthesised molecular structures are elucidated by ¹H-NMR, ¹³C-NMR, IR and mass spectral analysis and screened for their in vitro antimicrobial activity.

Graphic Abstract

The 1-(5-methyl-1-aryl-1H-1,2,3-triazol-4-yl)ethanone O-((1-aryl-1H-1,2,3-triazol-4-yl)methyl) oxime 5(a–p) were synthesised by using different substituted aromatic alkynes and aromatic azides by using Cu(I) as a catalyst under microwave irradiation method in good yields. The structure of the compounds was confirmed by spectral methods and evaluated for their in vitro antimicrobial activity.

中文翻译：

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微波合成一些新的1,2,3-三唑衍生物及其抗菌活性

摘要

在常规和微波辐射方法下，通过Cu（I）催化炔烃和有机叠氮化物的1,3-偶极环加成反应（即点击反应），设计并合成了一系列新的1,2,3-三唑衍生物。以CuI为催化剂，在微波辐射法下，在较短的时间内获得了较高的收率。在此，两个三唑部分通过O-烷氧基肟键连接。通过¹ H-NMR，¹³ C-NMR，IR和质谱分析阐明所有合成的分子结构，并筛选它们的体外抗菌活性。

图形摘要

1-（5-甲基-1-芳基-1 H -1,2,3-三唑-4-基）乙酮O -（（1-芳基-1 H -1,2,3-三唑-4-基在微波辐射法下，以Cu（I）为催化剂，通过使用不同的取代芳烃和芳族叠氮化物合成了（）甲基）肟5（a-p）。通过光谱方法确认化合物的结构，并评估其体外抗菌活性。